Science
Nanomedicine Technology
The Science of Dysregulated Macrophage Response
How Macrophage Activity Influences Wound Healing and Scar Formation
Macrophages are essential immune cells that coordinate inflammation and tissue repair. During normal wound healing, they clear damaged cells and pathogens before transitioning to functions that support tissue regeneration. When this process becomes dysregulated, prolonged inflammation, impaired repair signaling, and excessive fibroblast activation can disrupt normal tissue remodeling, leading to excessive collagen deposition, fibrosis, and abnormal scar formation.
CYTONECT™ Approach: Targeting the Source
Current scar-management approaches, including silicone gels, steroid injections, pressure garments, and laser therapy, primarily focus on managing scars after they become visible, rather than addressing the biological processes that drive excessive scar formation during wound healing.
CYTONECT™ has developed a proprietary, precision-targeted nanomedicine technology engineered to modulate macrophage activity during the early stages of wound healing.
By regulating macrophage inflammatory activity and supporting the timely transition from pro-inflammatory M1-like to repair-promoting M2-like phenotypes, our technology targets key biological mechanisms involved in dysregulated tissue remodeling.
This targeted approach is designed to regulate inflammation, support tissue repair, promote organized tissue remodeling, and reduce excessive scar formation.
Nanoscale and relatively uniform
Negative surface charge
Stable in 10% Fetal Bovine Serum (FBS)